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Comparison
of Statin Effects on Lipids After 8 Weeks of Treatment in Men and Women
With LDL-C From 192 to 244 mg/dL (N=534)*
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| Statin | Dosage Range (mg) |
Change
(%)
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| TC | LDL-C | HDL-C | TG | ||||||||
|
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| Lovastatin | 20-80 |  21
to 36 |
29
to 48 |
 4.6
to 8.0 |
12
to 13 |
||||||
| Pravastatin | 10-40 | 13
to 24 |
19
to 34 |
3.0
to 6.2 |
3
to 10 |
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| Simvastatin | 10-40 | 21
to 30 |
28
to 41 |
6.8
to 9.6 |
12
to 15 |
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| Fluvastatin | 20-40 | 13
to 19 |
17
to 23 |
0.9
to 3.0 |
5
to 13 |
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| Atorvastatin | 10-80 | 28
to 42 |
38
to 54 |
5.5
to 0.1 |
13
to 25 |
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*
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HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoproteins; TC = total cholesterol; TG = triglycerides. | ||||||||||
| Note: The lipid-lowering effect of the various statins in this study are representative of those seen in other controlled trials, with one exception. In the CARE, WOSCOPS, and LIPID trials, pravastatin had a slightly greater tryglyceride-lowering effect (11-14%). | |||||||||||
